The Evolving Landscape in the Care of Infants with Trisomy 13 and 18

Drawing on numerous studies, neonatologist Nandita Mandhani, MBBS, takes a deep and thoughtful dive into the issues that arise with prenatal diagnosis of these chromosomal disorders, as well as the care of affected newborns. While trisomy 13 and 18 are associated with defects and high mortality, certain factors and interventions inform survival rates, so delivering sensitive, evidence-based counseling is essential. Mandhani explains why providers shouldn’t make assumptions about the parental experience and offers tips on preserving patients’ trust.

Learning Objectives:

  • Describe the historical context in the management of infants with Trisomy 13 and 18.
  • Examine recent literature on outcomes and approaches in the care of these infants.
  • Recognize parental perspectives on lives with infants with Trisomy 13 and 18.
  • Assess recommendations and next steps in the care of these infants.


October 24, 2022


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Nandita Mandhani, MBBS

Nandita Mandhani, MBBS